• Lezcano E, Gómez-Esteban JC, Tijero B, Bilbao G, Lambarri I, Rodriguez O, Villoria R, Dolado A, Berganzo K, Molano A, de Gopegui ER, Pomposo I, Gabilondo I, Zarranz JJ

Long-term impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on health-related quality of life (HRQOL) and associated factors in patients with Parkinson's disease (PD) are not clear. In this prospective study, we included 69 PD patients (64 % men, mean age 61.3 ± 7.4 and disease duration 13.2 ± ...

• Carreiras M, Quiñones I, Mancini S, Hernández-Cabrera JA, Barber H

Agreement computation is one of the pillars of language comprehension. In this fMRI study, we investigated the neuro-cognitive processes of agreement associated with number feature covariance in subject-verb agreement and determiner-noun concord in Spanish by creating mismatches (ella/*ellas corre, she/*they dances vs. el/*los anillo, thesg/*thepl ring). The results evidenced the ...

• Galbarriatu L, Pomposo I, Aurrecoechea J, Marinas A, Agúndez M, Gómez JC, Acera MA, Martínez MJ, Valle E, Maestro I, Mateos B, Cabrera A, Fernández J, Iturri F, Garamendi I

Objective: Treatment-resistant epilepsy (TRE) occurs in 20-30% of patients. The goal of this study is to assess the efficacy and safety of vagus nerve stimulation (VNS) in this group of patients, including adult and pediatric populations and several off-label indications. Methods: This is a retrospective review of 59 consecutive patients in ...

• Frost R, Quiñones I, Veldhuizen M, Alava JI, Small D, Carreiras M

Over the last few decades, wine makers have been producing wines with a higher alcohol content, assuming that they are more appreciated by consumers. To test this hypothesis, we used functional magnetic imaging to compare reactions of human subjects to different types of wine, focusing on brain regions critical for ...

• Quiñones I, Molinaro N, Mancini S, Hernández-Cabrera JA, Carreiras M

Language comprehension is incremental, involving the integration of information from different words together with the need to resolve conflicting cues when unexpected information occurs. The present fMRI design seeks to segregate the neuro-anatomical substrates of these two processes by comparing well-formed and ill-formed sentences during subject–verb agreement computation. Our experiment ...

• Jiménez de la Peña M, Gil Robles S, Recio Rodríguez M, Ruiz Ocaña C, Martínez de Vega V

Objetivo Describir, con estudios funcionales de activación y tractografía en una RM de 3 Teslas (3 T), las áreas corticales y vías subcorticales implicadas en el lenguaje, y mostrar la buena correlación de estos estudios funcionales con la estimulación directa cortical y subcortical intraoperatoria. Material y métodos Presentamos una serie de 14 pacientes ...

• Gil-Robles S, Carvallo A, Jimenez Mdel M, Gomez Caicoya A, Martinez R, Ruiz-Ocaña C, Duffau H

BACKGROUND: Study of the corticosubcortical functional anatomy of reading and picture naming. OBJECTIVE: To study the role of the left basal occipitotemporal area and its white matter pathways. METHODS: Three patients underwent awake surgery for lesions in the left basal posterotemporal region with intraoperative electrostimulations. Intraoperative testing consisted of naming, reading, and ...

• Gil-Robles S

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• De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS

Purpose: Surgery for infiltrative gliomas aims to balance tumor removal with preservation of functional integrity. The usefulness of intraoperative stimulation mapping (ISM) has not been addressed in randomized trials. This study addresses glioma surgery outcome on the basis of a meta-analysis of observational studies. Methods: A systematic search retrieved 90 reports ...

• Gil-Robles S, Duffau H

Object: Recent surgical studies have demonstrated that the extent of resection is significantly correlated with median survival in WHO Grade II gliomas. Consequently, thanks to advances in intraoperative functional mapping, the authors questioned whether it is actually necessary to leave a "security" margin around eloquent structures. Methods: The authors first reviewed ...